Here are some players that are in the top 200 for Yahoo Fantasy Baseball but have struggled against today's pitchers in the past. They have more than 10 AB v that pitcher and a BA of less than 0.200 in the last 6 years.
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Carlos Pena (Cubs, 1B) v Carlos Vasquez (Marlins, SP)
Jose Bautista (Blue Jays, OF) v CC Sabathia (Yankees, SP)
Kevin Youkilis (Red Sox, 3B) v James Shields (Rays, SP)
Carlos Quentin (White Sox, OF) v Max Scherzer (Tiges, SP)
Ryan Howard (Phillies, 1B) v Jonathan Niese (Mets, SP)
Brandon Phillips (Reds) v Chris Carpenter (Cardinals, SP)
Jay Bruce (Reds) v Chris Carpenter (Cardinals, SP)
Ian Kinsler (Ranges) v Felix Hernandez (Mariner, SP)